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FLASH GENE
Symbol RPL13 contributors: mct - updated : 27-11-2019
HGNC name ribosomal protein L13
HGNC id 10303
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4499 24.2 211 - 1998 9582194
  • RPL13-V1
  • 5 splicing 4672 24.2 211 - 1998 9582194
    RPL13-V2
    7 - 4358 - 164 - 1998 9582194
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines Hela cell
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    highly basic protein with two potential nuclear localization signal (NLS)
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    text
  • highly expressed in the growth plate and in cells lining the newly primary bone trabeculae
  • basic FUNCTION
  • 60S ribosomal protein 13
  • RPL13 plays an essential role in the progression of some gastrointestinal malignancies
  • DDX3 cooperates with RPL13 to support the assembly of 80S ribosomes for optimal translation initiation of viral mRNA
  • role of RPL13 in bone development
  • could play a specific role in the translation of particular mRNAs in chondrocytes or/and osteoblasts of the growth plate
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of ribosome,large subunit
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SEMD7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    promoted senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
  • Therapy target
    ANIMAL & CELL MODELS