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FLASH GENE
Symbol TAF6 contributors: mct - updated : 02-06-2020
HGNC name TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
HGNC id 11540
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 splicing 2748 72.7 677 - 2014 25025302
- splicing 2380 - 667 - 2014 25025302
15 splicing 2707 - 667 - 2014 25025302
15 splicing 2424 72.7 677 - 2014 25025302
15 - 2433 - 714 - 2014 25025302
16 - 2880 - 677 - 2014 25025302
15 - 2718 - 667 - 2014 25025302
TAF6delta
16 - 2678 - 723 - 2014 25025302
16 - 2526 - 667 - 2014 25025302
TAF6delta
17 - 2526 - 677 - 2014 25025302
14 - 2394 - 667 - 2014 25025302
TAF6 delta
15 - 2269 - 667 - 2014 25025302
TAF6delta
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouth   highly
 salivary gland   highly
Endocrinethyroid   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small middle domain (TAF6M)
  • a large C-terminal domain (TAF6C)
  • HOMOLOGY
    Homologene
    FAMILY
  • TAF6 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • TAF6delta is a pro-apoptotic splice variant of the RNA polymerase II general transcription factor, TAF6, that can dictate life vs. death decisions i cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • BCL2L11 and PMAIP1 are mitochondrial effectors of TAF6delta-driven apoptosis
  • key checkpoint function for the chaperonin TCP1, which specifically associates with nascent TAF5 for subsequent handover to TAF6-TAF9 and ultimate holo-TBP formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALYUS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS