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FLASH GENE

Symbol

ATP6V0B

contributors: mct - updated : 05-11-2010

HGNC name	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
HGNC id	861

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001039457 7 - 979 NP_001034546 - 158 - 2003 128905 NM_004047 8 - 1028 NP_004038 - 205 - 2003 12890556

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   stomach       highly Nervous brain         Reproductive female system ovary         male system prostate     highly Respiratory lung         Skin/Tegument skin       highly Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	five putative transmembrane segments (5TM)
	a conserved glutamic and residue, essential for H+ transporting

HOMOLOGY

interspecies

homolog to yeast VMA16

Homologene

FAMILY

V-ATPase proteolipid subunit family

CATEGORY

enzyme , transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	ATPase H+ transporting, vacuolar proton pump, microvesicles and other acidic organelles (lysosomes)
	proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase
	coupling ATP hydrolysis to proton pumping across membranes
	conserved proton pumps that couple hydrolysis of cytosolic ATP to proton transport out of the cytosol
	important role for physical association between aldolase and V-ATPase in the regulation of the proton pump

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

energetic

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS