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FLASH GENE
Symbol HCRTR1 contributors: mct - updated : 07-07-2020
HGNC name hypocretin (orexin) receptor 1
HGNC id 4848
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2307 - 425 - 1998 9527442
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segment (7TM) receptor
HOMOLOGY
intraspecies homolog to HCRTR2
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • involved in the regulation of feeding behaviour
  • couple to adenylyl cyclase regulation via multiple mechanisms
  • orexin system modulates likely the formation and expression of fear memory via HCRTR1 in multiple pathways
  • endogenous hypocretins acting on the HCRTR1 are required for the normal neural activity in the medial prefrontal cortex (mPFC), and thus might directly contribute cortical arousal and mPFC-dependent cognitive processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • selectively binds the orexin A neuropeptide
  • activation of HCRTR1 was found to attenuate agonist-activated OPRK1-mediated inhibition of cAMP production
  • role of MRAP2 in the regulation of the orexin receptor 1 (HCRTR1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    HCRTR1 blockade suppresses endogenous phasic dopamine signals, likely via actions at dopamine cell bodies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoussleep 
    in contrast to GABA receptor agonists which induce sleep by generalized inhibition, HCRTR1 antagonists seem to facilitate sleep by reducing waking "drive"
    ANIMAL & CELL MODELS
  • Ox1r(-/-) mice showed impaired freezing responses in both cued and contextual fear-conditioning paradigms