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FLASH GENE
Symbol LSAMP contributors: mct/npt - updated : 09-06-2020
HGNC name limbic system-associated membrane protein
HGNC id 6705
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 9478 - 338 - 2003 14667507
9 - 9485 - 361 - 2003 14667507
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic system  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three Ig domains and a glycosyl-phosphatidylinositol anchor
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • immunoglobulin superfamily
  • plasticity-associated IgLON family neural adhesion molecules
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text the surface of somata and proximal dendrites
    basic FUNCTION
  • mediating selective neuronal growth and axon targeting
  • neuronal surface glycoprotein found in the cortical and subcortical regions of the limbic system
  • LSAMP and NTM promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions
  • function as a tumor suppressor gene in clear cell renal cell carcinoma
  • neuronal adhesive molecule, preferentially expressed in developing limbic system neuronal dendrites and somata (Must 2008)
  • might play a role in pathoaetiology of suicidal behaviour (Must 2008)
  • candidate tumor suppressor gene in osteosarcomas (Kresse 2009)
  • is a neural cell adhesion molecule involved in neurite formation and outgrowth
  • is involved in emotional and social operating systems by complex regulation of two alternative promoters
  • role for ADAM10-dependent shedding of cell surface LSAMP in promoting outgrowth from dorsal root ganglion cells (DRGs) neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interplay between LSAMP and NTM in regulating tissue homeostasis: the impact of NTM on cellular proliferation was dependent on LSAMP, and LSAMP appeared to be a positive regulator of apoptosis in the presence of NTM
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in osteosarcoma (Yen 2009)
    tumoral   deletion    
    in osteosarcomas (Kresse 2009)
    tumoral     --over  
    of the LSAMP and TUSC7 genes in acute myeloid leukemia
    Susceptibility
  • to late-onset coronary artery disease (CAD)
  • to ulcerative colitis (UC)
  • to schizophrenia
  • Variant & Polymorphism SNP
  • increasing the risk of late-onset coronary artery disease (CAD)(Wang 2008)
  • SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for UC
  • significant allelic and haplotypic associations between LSAMP gene and schizophrenia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS