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FLASH GENE
Symbol NR6A1 contributors: mct - updated : 18-03-2008
HGNC name nuclear receptor subfamily 6, group A, member 1
HGNC id 7985
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1918 54 480 - Susens, Rajkovic (2004)
10 - 1903 - 476 - Susens, Rajkovic (2004)
- - 4129 - 454 - Susens
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Reproductivefemale systemplacenta  highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal modulator domain
  • a central bipartite zinc finger
  • a DNA binding domain
  • a C terminal ligand domain
  • HOMOLOGY
    Homologene
    FAMILY
  • nuclear receptor subfamily 6, group A
  • steroid/thyroid receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • germ cell nuclear receptor, potentially involved in spermatogenic maturation
  • required for establishment of the isthmic organizer, thereby regulating the midbrain development
  • playing a central role during differentiation of stem cells by repression of stem cell-specific genes
  • works as a regulator for hypocretin transcription
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with UIMC1
    cell & other
    REGULATION
    Other regulated by UIMC1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS