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FLASH GENE
Symbol DMTF1 contributors: mct/npt/pgu - updated : 18-08-2009
HGNC name cyclin D binding myb-like transcription factor 1
HGNC id 14603
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3801 - 760 - 2003 12917399
- - 3933 - 272 - 2003 12917399
antagonizes DMTF1 alpha activity
- - 3972 - 285 - 2003 12917399
17 - 3684 - 672 - 2003 12917399
20 - 4052 - 760 - 2003 12917399
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three imperfect myb repeats
  • flanked by N and C terminal acidic transactivating domains
  • HOMOLOGY
    Homologene
    FAMILY
  • DMTF1 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in the spliceosome
    basic FUNCTION
  • potential inhibitor of cell cycle S phase entry
  • putative up or downregulated MYC target gene, regulating cell proliferation
  • Ras-activated transcription factor that can stimulate CDKN2A transcription to promote TP53-dependent cell arrest
  • physiological regulator of the Arf-TP53 pathway
  • RAS/ERBB2-activated haplo-insufficient tumor suppressor that activates the CDKN2A/TP53 pathway of cell-cycle arrest
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by cellular DMTF1 isoform levels
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS