Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ADAM22 contributors: npt/mct - updated : 10-05-2017
HGNC name ADAM metallopeptidase domain 22
HGNC id 201
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
31 - 3445 100 906 normal brain, not expressed in high grade glioma 2003 12589811
isoform epsilon 1
32 splicing 3393 - 899 - 2003 12589811
  • isoform delta 2
  • lacking exon 2
  • 30 splicing 3347 - 870 most abundant transcript in glioma 2003 12589811
  • isoform beta 4
  • lacking exon 2
  • 29 splicing 2744 - 859 not expressed in glioma 2003 12589811
    isoform beta 4
    28 splicing 2636 - 823 - 2003 12589811
  • isoform 5
  • lacking exon 2
  • 32 - 9623 - 963 absent in normal brain, only in glioma 2003 12589811
    lacking exon 2
    32 - 9626 - 964 not expressed in glioma 2003 12589811
    34 - - - - overexpressed inglioma 2003 12589811
    31 - 9539 - 935 low expressed in normal brain, overexpressed in glioma 2003 12589811
    lacking exon 2
    29 - 9220 - 890 expressed in one glioma specimen only 2003 12589811
    38 - - - - - 2003 12589811
    35 - - - - - 2003 12589811
    34 - - - - - 2003 12589811
    30 - 9341 - 869 - 2003 12589811
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainlimbic systemhippocampus highly
     brainhindbraincerebellum highly
     nervecranial nerve   
     spinal cord   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • a disrupted Zn-binding site metalloproteinase
  • a disintegrin-like domains
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane domain and a cytoplasmic tail
  • a peptidase M12B domain
  • extracellular domain interacting with LGI1, whereas its cytoplasmic PDZ-binding motif recruits DLG4 (Liu 2009)
  • ectodomain comprising four domains assembled together like a four-leaf clover, and each leaf represents one of the four domains including :
  • the metalloproteinase-like domain (domain M, residues 233–435)
  • the disintegrin domain (domain D, residues 445–529)
  • the cysteine-rich domain (domain C, residues 530–676)
  • the epidermal growth factor-like domain (domain E, residues 677–718) (Liu 2009)
  • conjugated GlycoP , MetalloP
    isoforms Precursor the propeptide of ADAM22 is essential for ADAM22 secretion and may play an intramolecular chaperone function, similar to the cases of ADAM17 and ADAM12
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the postsynaptic density by cytoskeletal scaffolds containing stargazin
    basic FUNCTION
  • involved in cell-cell and cell-matrix interactions integrin ligand in the brain
  • brain-specific cell surface protein, mediates growth inhibition using an integrin dependent pathway
  • non-catalytic ADAMs, recently identified to serve as the postsynaptic receptor for the secreted neurotransmission modulator LGI1 at neural synapses (Liu 2009)
  • by finely regulating the synaptic AMPA receptors, the LGI1-ADAM22 interaction maintains likely physiological brain excitability throughout life
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • form a tertiary complex with postsynaptic density-95 (DLG4), a major scaffolding protein localized to the postsynaptic density of brain synapse (Liu 2009)
  • LGI1 and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of DLG4
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • three putative calcium ions bound to ADAM22
  • protein
  • probable ligand for integrin in the brain
  • coupling to LGI1, enhancing AMPA receptor-mediated synaptic transmission in hippocampal slices
  • interacting with LGI1 (LGI1acts as a ligand that selectively binds to the postsynaptic receptor ADAM22, thereby regulating the glutamate-AMPA neurotransmission)
  • interaction with YWHAZ (can regulate cell adhesion and spreading, therefore it has a potential role in neural development and function)
  • with ADAM11 and ADAM23, binds LGI1 and LGI4 (LGI-ADAM system seems to be regulated not only by the affinity but also by the cell-type-specific expression of each protein) (Sagane 2008)
  • critical roles of a ligand-receptor complex, LGI1-ADAM22, in synaptic transmission and brain function
  • is a ligand secreted by Schwann cells that regulates peripheral nerve myelination via its cognate receptor ADAM22 expressed by neurons
  • ADAM22 and ADAM23 modulate the trafficking of LGI1, and promote its ER export and expression at the overall neuronal cell surface
  • ADAM22 may be an LGI3 receptor in human keratinocytes (PMID/
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEECA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    high-grade but not low-grade gliomas
    tumoral     --low  
    low expression levels of LGI3, ADAM22 and ADAM23 were significantly associated with poor prognosis of glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS