basic FUNCTION
| participating in the interaction between leukocytes and the endothelium and may be involved in the pathogenesis of atherosclerosis |
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plays critical roles in tethering leukocytes to endothelial cells (ECs) |
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pivotal molecule for endothelial progenitor cells homing to ischemic limb and vasculogenesis |
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during inflammation, SELE-expressed on cytokine-activated endothelial cells mediates leukocyte rolling under flow |
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SELE clusters in both clathrin-coated pits and lipid rafts of endothelial cells but is internalized in clathrin-coated pits |
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expressed by cardiac fibroblasts with ICAM1 and CXC chemokines in response to proinflammatory cytokine stimulation in the infarcted myocardium |
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might be an important factor involved in the process of cerebral aneurysm formation and rupture, by promoting inflammation and weakening cerebral artery walls |
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role of endothelial cell adhesion molecules SELP, SELE and ICAM1 in leucocyte recruitment induced by exogenous methylglyoxal in diabetes |