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FLASH GENE
Symbol ISG20 contributors: npt/ - updated : 18-07-2008
HGNC name interferon stimulated exonuclease gene 20kDa
HGNC id 6130
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 974 20.2 181 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus    
Digestiveintestinelarge intestinecolon  
 liver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lysine and arginine rich domain
  • coiled-coil structure bordered by potential phosphorylation sites
  • HOMOLOGY
    interspecies homolog to Xenopus XPMC2
    ortholog to murine Isg20
    Homologene
    FAMILY
  • exonuclease superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text colocalized with PML and SP100 gene products within the nuclear bodies
    basic FUNCTION
  • acting as an exonuclease
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PML
  • SP100
  • cell & other
    REGULATION
    induced by estrogen
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS