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FLASH GENE
Symbol PRM2 contributors: mct/npt - updated : 17-07-2008
HGNC name protamine 2
HGNC id 9448
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 683 13 102 - Hammoud (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemtestis   
Urinarykidney    
cell lineage
cell lines
fluid/secretion spermatid specific
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Prm2
homolog to C.elegans B0310.4
Homologene
FAMILY
  • protamine P2 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text nucleosome
    basic FUNCTION
  • substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis
  • basic chromosomal protein that replace the histones during chromatin remodeling
  • during mammalian spermatogenesis, involved in the substantial condensation of the chromatin structure (Kempisty 2007)
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • spermatogenesis
  • mitotic chromosome condensation (DNA packaging)
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduction in contents of PRM1 and PRM2 transcripts in spermatozoa may be linked with asthenozoospermia (Kempisty 2007)
    Susceptibility to male infertility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS