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FLASH GENE
Symbol GSTM3 contributors: mct - updated : 17-07-2008
HGNC name glutathione S-transferase M3 (brain)
HGNC id 4635
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3948 25 225 - Ikeda (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Nervousbrain    
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Gstm3
homolog to C.elegans T28A11.11
Homologene
FAMILY
  • GST superfamily
  • mu family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • establishment of blood/nerve barrier
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text germline maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hypertension
  • to Alzheimer disease
  • Variant & Polymorphism other polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS