SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| intracellular,nuclear envelope
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text
| expressed in target of the mitochondria, when inducing apoptosis |
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colocalizing with HSPD1 |
basic FUNCTION
| inhibiting growth of cancer cells |
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promoting apoptosis and repressing survival genes |
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playing a role in tumor suppression |
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required for the selective elimination of mitochondria |
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playing a critical role in programmed mitochondrial clearance during reticulocyte maturation |
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crucial for hypoxia-induced autophagy by disrupting the Bcl2-beclin1 complex without inducing cell death, promoting tumor progression |
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may function simultaneously with BNIP320 |
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can overcome the suppressors BCL2 and BCLXL, although high levels of BCLXL expression will inhibit apoptosis |
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functioning as a mitophagy-specific receptor through the direct interaction with the Atg8 homologues |
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functions by causing mitochondrial depolarization, activating autophagy, or engaging the autophagy machinery |
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plays a critical role in pressure overload-induced cardiac remodeling and heart failure through mediating cardiomyocyte apoptosis |
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is a mitochondrial outer membrane protein that is required for the selective clearance of mitochondria 2) |
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BNIP3 regulates mitophagy during hypoxia, whereas BNIP3L is required for mitophagy during development of the erythroid lineage |
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temporally regulated role for BNIP3 and BNIP3L in the generation of robust NK cell memory |
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BNIP3L-dependent mitophagy results in a metabolic shift towards glycolysis essential for retinal ganglion cell (RGC) neurogenesis |
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BNIP3L-dependent mitophagy regulates cell differentiation via metabolic reprogramming |
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involvement of BNIP3L/NIX in cerebral ischemia-reperfusion (I-R)-induced mitophagy |