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FLASH GENE
Symbol SDHC contributors: mct/ - updated : 07-05-2019
HGNC name succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
HGNC id 10682
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2694 - 150 - 2018 29126304
6 - 2858 - 169 - 2018 29126304
4 - 2699 - 116 - 2018 29126304
5 - 2756 - 135 - 2018 29126304
4 - 2592 - 116 - 2018 29126304
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver    
Endocrineparathyroid   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • hydrophobic integral membrane-anchor peptide
  • secondary structure four nuclear encoded subunit (A,B,C,D)
    HOMOLOGY
    interspecies homolog to C.elegans t07c4.7
    Homologene
    FAMILY
  • cytochrome b560 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • succinate-ubiquinone oxidoreductase, catalyzing the seventh step of the citric acid cycle (tricarboxylic acid cycle)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism organic acid
    signaling
    a component
  • component 3 of complex II of mitochondrial respiratory chain (CII-3), oxidative phosphorylation,(OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PGL3
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in familial and sporadic paraganglioma
    tumoral       loss of function
    in paraganglioma and pheochromocytoma
    tumoral germinal mutation      
    increases oxidative stress, resulting in apoptosis and tumorigenesis
    tumoral       loss of function
    epigenetic inactivation of the SDHC gene locus with functional impairment of the SDH complex is a plausible alternate mechanism of tumorigenesis in Carney triad (CT)
    Susceptibility to head and neck paraganglioma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS