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FLASH GENE
Symbol DHX15 contributors: mct/npt - updated : 30-10-2017
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 15
HGNC id 2738
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3019 - 795 - 2017 28115624
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunethymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp-Glu-Ala-His)
  • N terminal RGD motif,an Arg-Asp repeat (RD) RNA binding motif
  • N terminal helicase domain, and N-terminal domain containing a DEXDc motif bound the C terminus of MAVS
  • C terminal helicase associated domain
  • HOMOLOGY
    interspecies ortholog to yeast Prp43
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • DDX15/PRP43 sub-subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • DEAH-box RNA-dependent ATPase that catalyzes the release of excised lariat intron from the mRNA spliceosome
  • putative ATP-dependent RNA helicase implicated in pre-mRNA splicing
  • in cooperation with TFIP11 mediates the transition from the intron large complex to the intron small complex, leading to efficient debranching and turnover of excised introns (Yoshimoto 2009)
  • DHX15 activates NFKB1 and MAPK signaling downstream of MAVS during antiviral responses
  • is a new RNA virus sensor mediated by MAVS to activate the immune responses to RNA
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text preRNA splicing
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SSB (may be colocalized in the nucleoli)
  • interacting with TFIP11 (protein component of the spliceosome complex that promotes the release of the lariat-intron during late-stage splicing through a direct recruitment and interaction with DHX15) (Tannukit 2009)
  • DHX15 and PRPF19, two spliceosome components, are novel RBM5-interacting partner
  • DHX15 physically interacted with MAVS and mediated the MAVS-dependent activation of the NFKB1 and MAPK pathways
  • NLRP6 functions with DHX15 as a viral RNA sensor to induce IFN-stimulated genes (ISGs), and this effect is especially important in the intestinal tract
  • NKRF mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis
  • DHX15 regulates AR activity by modulating E3 ligase SIAH2-mediated AR ubiquitination independent of its ATPase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS