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FLASH GENE
Symbol DTNB contributors: mct/npt - updated : 20-05-2016
HGNC name dystrobrevin, beta
HGNC id 3058
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2509 71.3 627 - 1998 9540997
variant 1-isoform 1
20 - 2439 - 597 - 1998 9540997
  • variant 2-isoform 2
  • 19 - 2307 - 567 - 1998 9540997
    18 - 2328 - 560 - 1998 9540997
  • variant 5
  • 20 - 2453 - 609 - 1998 9540997
    18 - 2328 - 545 - 1998 9540997
    20 - 2486 - 620 - 1998 9540997
    18 - 2191 - 602 - 1998 9540997
    - - 2299 - 398 - 1998 9540997
    - - 2418 - 590 - 1998 9540997
    - - 2439 - 597 - 1998 9540997
    - - 2267 - 416 - 1998 9540997
    - - 2854 - 625 - 1998 9540997
    - - 1357 - 318 - 1998 9540997
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
     brainforebraincerebral cortex  
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger ZZ type
  • HOMOLOGY
    intraspecies paralog to DTNA,significantly
    homolog to dystrophin
    Homologene
    FAMILY
  • dystrophin associated complex family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the formation and stability of synapses
  • may play an important role in intracellular signal transduction, in addition to providing a membrane scaffold in muscle
  • having a function as a motor protein receptor that might play a major role in the transport of components of the dystrophin-associated protein complex to specific sites in the cell
  • role for dystrobrevin as a scaffold protein that may play a role in different cellular processes involving PRKAR1A signaling
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
  • copurifying with DP71 and DP140 dystrophins
  • component of the dystrophin glycoprotein complex with dystrophin, syntrophins DNTB1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind directly to dystrophin and are components of a transmembrane dystrophin-glycoprotein complex (DGC) that links the cytoskeleton to extracellular proteins in many tissues
  • binds to RE-1 and represses the promoter activity of synapsin I, a REST-responsive gene that is a marker for neuronal differentiation
  • direct interaction witht HMG20A and HMG20B, suggesting that DTNB may be involved in regulating chromatin dynamics, possibly playing a role in neuronal differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • synaptic and behavioral abnormalities are minimal in mice lacking either Dtna or Dtnb