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FLASH GENE
Symbol CHD5 contributors: - updated : 11-06-2007
HGNC name chromodomain helicase DNA binding protein 5
HGNC id 16816
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   moderately
Endocrineadrenal gland    
Lymphoid/Immunethymus   moderately
Nervousbrainhindbraincerebellum highly
Reproductivemale systemtestis  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a paired PHD type (C4-H-C3) zinc finger motif
  • two DNA binding chromodomains toward the N terminal
  • a central helicase ATPase related SNF2 domain
  • an helicase C-terminal domain
  • a region with similarity to the Myb-DNA binding domain
  • a DEAH box
  • conjugated HemoP
    HOMOLOGY
    interspecies homolog to chimpanzee CHD5 (98.1 pc)
    homolog to murine Chd5 (94.9 pc)
    homolog to C. elegans chd-3 (55.3 pc)
    intraspecies homolog to CHD3
    homolog to CHD4
    Homologene
    FAMILY
  • CHD family
  • chromodomain SNF2/RAD54 helicase subfamily
  • CATEGORY enzyme , regulatory , DNA associated , transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may play a role in the development of the nervous system and the pathogenesis of neural tumors
  • acting as an ATP-dependent helicase
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • nervous system development
  • PATHWAY
    metabolism
    signaling
    a component component of the chromatin remodeling complex
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in neuroblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS