basic FUNCTION
| cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells |
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playing an important role in osteoclastogenesis |
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differential involvement of ITGAX and ITGAM in adhesion and subsequent cytoskeletal changes in monocytes exposed to different conditions indicates the importance of each integrin in distinct responses during inflammation (Georgakopoulos 2008) |
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marked differences in the signaling requirements for expression of ENPP3 and ITGAM versus CD63 expression and histamine release in human basophils |
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role of ITGAM in maintaining autoreactive B cell tolerance |
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ITGAM-mediated atrial polymorphonuclear neutrophils (PMN) infiltration linked to the formation of fibrosis, which promotes the initiation and propagation of atrial fibrillation (AF) |
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plays a critical role in obesity-induced insulin resistance by limiting the proliferation and alternative activation of adipose tissue macrophages (ATMs) |
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novel role for ITGAM in the regulation of soluble beta-amyloid (APP) clearance independent of phagocytosis |
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function of ITGAM in antibody responses and the role of CD11b as a vital regulator of class switch recombination (CSR) |