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FLASH GENE
Symbol RRP8 contributors: mct/npt - updated : 05-10-2016
HGNC name ribosomal RNA processing 8, methyltransferase, homolog (yeast)
HGNC id 29030
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1699 - 456 - 2000 10864042
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • motifs found in methyltransferases (Bousquet-Antonelli 2000)
    • HOMOLOGY
    interspecies homolog to yeast S.pombe C56F8-09 protein
    homolog to Drosophila CG7137
    homolog to C.elegans T07A9.8
    Homologene
    FAMILY
  • methyltransferase superfamily
  • RRP8 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text localizes to the nucleolus (Bousquet-Antonelli 2000)
    basic FUNCTION
  • methyltransferase activity
  • nucleolar protein functionally linked to GAR1 and involved in pre-rRNA cleavage at site A2 (Bousquet-Antonelli 2000)
  • nucleolar protein, important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which also contains SIRT1 and SUV39H1
  • RRP8 complex promotes rDNA heterochromatin formation and represses rRNA transcription
  • is required for the N(1)-methyladenosine (m(1)A) modification in 28S rRNAs of human cells
  • also contributes to 60S ribosomal subunit formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NMNAT1 interacts with the nucleolar repressor protein RRP8 and is involved in regulating rRNA transcription
  • RRP8-SIRT1 interaction was competitively inhibited by rRNA
  • RRP8-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a TP53-dependent manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS