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FLASH GENE
Symbol SGSM2 contributors: mct - updated : 29-09-2014
HGNC name small G protein signaling modulator 2
HGNC id 29026
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 4882 - 1051 - 2007 17509819
21 - 4775 - 1006 - 2007 17509819
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Nervousnerve   highly
Reproductivefemale systemuteruscervix highly
 male systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RUN and TBC motifs
  • RAPID motifs
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid C38H2
    Homologene
    FAMILY SGSM family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • modulator of the small G protein RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways
  • influenced the ability of RAB32 to bind its effector protein, ANKRD27, consistent with a physiological role for SGSM2 in regulating RAB32
  • multidomain protein binding RAB9A in a nucleotide-dependent manner but serves as a GAP for at least one other Rab GTPase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with RAP family proteins via novel RAP interacting domain (RAPID) motif
  • interact with several members of RAB family
  • RAB9A binding did not influence GAP activity of bead-bound SGSM2 protein
  • potential involvement of RAB9A in the regulation of the SGSM2 localization and in the trafficking of melanogenic enzymes (RAB32, RAB38, TYRP1)
  • functions as a GTPase-activating protein for RAB32/38 and regulates melanogenic enzyme trafficking in melanocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS