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FLASH GENE
Symbol EIF3E contributors: mct/npt - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 3, subunit E
HGNC id 3277
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1516 - 445 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 salivary gland   highly
Endocrineneuroendocrinepituitary   
Hearing/Equilibriumearinnercochlea highly
Urinarybladder   highly
cell lineage
cell lines Hela cells
fluid/secretion
at STAGE
physiological period embryo
Text neural crest, notocord, cartilage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PCI (PINT) proteasome (Int-6, Nip-1, TRIP15) motif
  • HOMOLOGY
    interspecies ortholog to murine Int-6
    Homologene
    FAMILY
  • eukaryotic translation initiation factor family
  • CATEGORY RNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • involved in association with eIF3, in routing specific mRNAs for degradation
  • involved in the quality control of specific mRNAs, the abundance of which is regulated by nonsense-mediated mRNA decay (NMD)
  • stabilizes chromatin-bound MCM7 and alteration of this effect is associated with replication deficiency (Buchsbaum 2007)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text regulation of translation
    PATHWAY
    metabolism
    signaling
    a component
  • components of the EIF3 multiprotein complex, 600kDa, subunit (EIF3E) of the eukaryotic translation initiation factor EIF3
  • component of the 26S proteosome
  • component of the COP9 signalosome, 450kDa
  • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • EIF3SIP
  • interaction with MCM7 (removal of MCM7 from chromatin as replication proceeds was accelerated in EIF3E-silenced cells and reduced amounts of protein were transiently observed, followed by a correction resulting from stimulation of MCM7 gene expression)(Buchsbaum 2007)
  • EIF4G1 protein binds to EIF3C, EIF3D, and EIF3D to promote mRNA recruitment to the ribosome
  • cell & other
    REGULATION
    Other excluded from PML nuclear bodies by binding to the HTLV-1 oncoprotein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    of ten deleted in primary breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS