basic FUNCTION
| acting as a receptor for medium and long chain saturated and unsaturated fatty acids |
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binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion |
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acting as a rhodopsin-like receptor |
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playing a dual role in the regulation of glucose homeostasis in diet-related type II diabetes |
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playing an important role for the beta-cell function |
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its acute activation potentiates insulin secretion from beta cells, whereas prolonged binding might contribute to the deleterious effects of chronic exposure to long-chain fatty acids |
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correlation with insulin secretion, raises the possibility of an involvement of FFAR1 in diabetes beta-cell dysfunction |
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implicated in mediating both physiological and pathological effects of fatty acids on beta-cells |
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plays a role not only in fatty acid modulation of insulin secretion, but also in glucose-induced insulin secretion after high-fat feeding |
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partially required for insulin secretion following activation of beta3-adrenergic receptors |
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FFAR1 and FFAR4 mediate the taste of fatty acids |
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is involved in both the acute and chronic effects of palmitate on insulin secretion |
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hypothalamic FFAR1 activated by free long chain fatty acids might have an important role in this pain control system |
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FFAR1, FFAR4 are two GPCRs activated by saturated and unsaturated longer-chain free fatty acids |
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is the functionally dominant free fatty acid receptor in airway smooth muscle |
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is a free fatty acid receptor that has been recently shown to impact bone remodeling |
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differentially impacts osteoblast behavior depending on differentiation stage and environment |
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mediating enhancement of glucose-stimulated insulin secretion |