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FLASH GENE

Symbol

CNN2

contributors: mct/npt - updated : 08-03-2010

HGNC name	calponin 2
HGNC id	2156

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004368 7 - 2478 NP_004359 33.6 309 - Hossain (2003) NM_201277 6 - 2361 NP_958434 29.4 270 - Hossain (2003)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Digestive liver         Endocrine pancreas         Reproductive female system breast         male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Muscular smooth     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

growth/childhood, ageing

Text	upregulated in the stomach and bladder during postnatal development, but is decreased to low levels in quiescent smooth muscle cells (Hossain 2003)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one calponin homology domain

HOMOLOGY

interspecies

homolog to murine Cnn2

intraspecies

homolog to non-muscle calponin CNN3,closely

Homologene

FAMILY

calponin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	may be involved in the structural organization and/or anchorage of actin filaments and may function in the cell adhesion mechanism
	conserved mechanism for its role in regulating actin filaments in smooth muscle and non-muscle cells (Jin 2003)
	may regulate cytokinesis by inhibiting the activity of the actin cytoskeleton (Hossain 2003)
	represents a novel manifestation of mechanical tension responsive gene regulation that may modify cytoskeleton function (Hossain 2005)
	actin-binding protein implicated in cytoskeletal organization (Tang 2006)
	plays an important role in the migration of endothelial cells both and its expression is critical for proper vascular development (Tang 2006)
	role in regulating macrophage motility and phagocytosis (Huang 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	actin, calmodulin, tropomyosin binding
	bind F-actin with similar affinity as CNN1 (Jin 2003)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS