basic FUNCTION
| ubiquitin specific protease, hydrolyzing isopeptide bonds between UB and folded protein domains such as additional UB mioetis or target proteins |
|
its function is essential for growth factor receptor down-regulation, and regulation of endosomal ubiquitin dynamics is essential for receptor down-regulation |
|
regulates the level of protein ubiquitination on endosomes, which is required for maintaining the morphology of the organelle |
|
can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation |
|
regulating endosomal ubiquitin dynamics and essential for receptor down-regulation |
|
playing central and nonredundant role in growth regulation, endosomal sorting, and the control of several growth factor receptor tyrosine kinases (RTKs) |
|
regulates cargo sorting and membrane traffic at early endosomes |
|
with STAMBP are essential for trafficking and down-regulation of F2RL1 but not for regulating F2RL1 dissociation from beta-arrestin2 or F2RL1-mediated ERK2 activation |
|
regulator of HGS function with consequences for the stability of receptors subject to HGS-dependent endocytosis |
|
deubiquitinating activity of USP8 is required for trafficking of CXCR4 between the early and late endosomal compartments |
|
modulates HGS ubiquitination to regulate endosomal ubiquitin dynamics and trafficking through the ESCRT-0 checkpoint |
|
implicated in control of a highly topical and medically relevant plasma membrane receptor |
|
USP8 regulates the rate of KCNN4 degradation by deubiquitylating KCNN4 prior to lysosomal delivery |
|
positive regulator in HH signaling by down-regulating SMO ubiquitination and thereby mediating SMO intracellular trafficking |
|
role for USP8 in the control of SCNN1A ubiquitination and trafficking |
|
controls the trafficking and sorting of lysosomal enzymes |
|
is critical for parkin-mediated mitophagy |
|
preferentially removes non-canonical K6-linked ubiquitin chains from parkin, a process required for the efficient recruitment of parkin to depolarized mitochondria and for their subsequent elimination by mitophagy |
|
BIRC6 and USP8 are two hitherto uncharacterized critical DNA damage response (DDR) regulators |
|
USP8-sorted cargo contributes early to acrosomogenesis and its trafficking is microtubule-mediated |
|
USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5 |
|
|