basic FUNCTION
| inhibiting MADH2 and MADH4 action |
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binding TGFB1 receptor and antagonizing TGFB signaling pathway |
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cooperates with MyoD, creating a positive loop to induce Smad7 expression and to promote MyoD driven myogenesis. Taken together, these data implicate Smad7 as a fundamental regulator of differentiation in skeletal muscle cells |
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intracellular mediator of TGFB family of cytokines |
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increasing resistance against TGFB-mediated apoptosis(substantial growth advantage for the tumor) |
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antagonistic SMAD |
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antagonizing activin pathway |
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negative regulator for the signaling of TGFB family members |
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adaptor in an E3 ubiquitin ligase complex targeting TGFBR for degradation |
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cooperates with MYOD1, creating a positive loop to induce SMAD7 expression and to promote MYOD1 driven myogenesis |
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being a fundamental regulator of differentiation in skeletal muscle cells |
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inhibits the phosphorylation of beta-catenin by interacting with Axin, modulating cell-cell adhesion and playing a role in inhibition of tumor metastasis |
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in prechondrogenic cells inhibits chondrocyte differentiation possibly by down-regulating BMP-activated MAPK14 pathways |
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inhibits chondrocyte differentiation and/or proliferation induced by TGFB or BMP |
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may be required for cardiac development in embryonic stage and cardiac function in adult |
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key negative regulator of TGFB signalling |
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TBX1 acts upstream of SMAD7 controlling vascular smooth muscle and extracellular matrix investment of the fourth arch artery |
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cell-intrinsic inhibitor of TGFB1 signaling, is sufficient to directly convert pluripotent hESCs to an anterior neural fate |
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is a negative regulator for TGFB1 signaling pathway through feedback regulation |
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novel role for SMAD7 as a transcriptional coactivator for CASP8 through the interaction with IRF1 in regulation of the cell death pathway |
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may be an important mediator for IFNG-induced CASP8 expression |
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SMAD7 may be required to mediate cell stress responses in the growth plate during development |
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functional role for SMAD7 in sustaining colon cancer cell growth and survival |
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novel key regulator between osteogenesis and osteoclastogenesis |
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enhances cell survival against DNA damage by accelerating ATM dependent DNA repair signaling |
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critical function of SMAD7 in DSB response |
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is a fundamental factor in the maintenance of epithelial growth of epithelial ovarian carcinoma (EOC) cells |
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is an important regulator of muscle growth |
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novel role of SMAD7 as promoter for prolonging the EGFR signal in keratinocyte and skin tissue by reducing its ligand-induced ubiquitination and degradation |
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