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FLASH GENE
Symbol UBE2E2 contributors: - updated : 11-07-2007
HGNC name ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
HGNC id 12478
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinnercochlea highly
Nervousnervecranial nerve  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
  • a unique N terminal extension
  • HOMOLOGY
    interspecies homolog to yeast UBC4/5
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • major ISG15-conjugating enzyme, involved in selective protein degradation
  • CELLULAR PROCESS cell cycle, checkpoint
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a complex with UBE1, UBE2D1, UBE2DG1, CBL, UBE3 ubiquitination complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS