basic FUNCTION
| renal reabsorption transporter of physiological nucleosides, pyrimidines, adenosin and drugs |
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concentrative nucleoside transporter, sodium dependent |
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mediating the cellular uptake of naturally occurring pyrimidine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs |
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SLC28A1, SLC28A2 are pyrimidine and purine nucleoside-selective, respectively |
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mediates the uptake of naturally occurring pyrimidine nucleosides, but also nucleoside analogs used in anticancer and antiviral therapy |
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fits the profile of a transceptor in a substrate translocation-independent manner and is likely to be relevant to tumor biology |
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is implicated in sensitizing solid tumors to nucleoside analogs |
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is a putative determinant for nucleoside analog chemoresistance in ovarian cancer |