Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CLIC2 contributors: mct - updated : 10-10-2017
HGNC name chloride intracellular channel 2
HGNC id 2063
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2702 - 247 - 2007 1794525
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiens
Muscularstriatumskeletal highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four beta strand
  • glutathione S-transferase domain
  • thioredoxin-like domains
  • a glutathione binding site where glutathione can form a disulfide bond with a conserved active site cysteine residue positioned near the N-terminal end of helix 1
  • CXXC active site motif conserved between CLIC2 and the glutaredoxins
  • an intramolecular disulfide and the protein remains monomeric irrespective of redox conditions
  • an extended loop region from the C-terminal domain, called the foot loop, inserting itself into an interdomain crevice of a neighboring molecule
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans f26h11.5
    intraspecies homolog to CLIC1
    Homologene
    FAMILY p64 family (chloride channel)
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • translocated from actin-enriched plasma membrane bundles to cell-cell junctions upon activation of NK2 receptors
  • basic FUNCTION
  • regulating fundamental cellular processes including stabilization of cell membrane
  • may be having a function to limit Ca2+ release from internal stores in cells
  • functions as an intrinsic stabilizer of the closed state of RYR channels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homodimerizing to form a potential pore
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • might potentially recognize other proteins such as the ryanodine receptor through a similar interaction
  • can interact with RYR1 and modulate its channel activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRXS32
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS