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FLASH GENE
Symbol SCN2B contributors: mct/ - updated : 05-07-2004
HGNC name sodium channel, voltage-gated, type II, beta
HGNC id 10589
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4922 24.2 215 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal large extracellular domain containing a Ig-V type fold with a disulfide bond and four N-linked glycosylation sites
  • a single transmembrane segment
  • a short intracytoplasmic C terminal tail
  • HOMOLOGY
    interspecies homolog to rattus contactin (with human auxilliary subunit beta)
    intraspecies homolog to myelin protein zero, highly
    Homologene
    FAMILY
  • sodium channel auxiliary subunit SCN2B family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • sodium channel, voltage-gated, type II,involved in the initiation and conduction of electrical impulses in nerves
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    Susceptibility to atrial fibrillation
    Variant & Polymorphism SNP R28Q, R28W associated with atrial fibrillation (Watanabe 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS