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FLASH GENE
Symbol CDK2AP1 contributors: mct - updated : 10-02-2016
HGNC name CDK2-associated protein 1
HGNC id 14002
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1655 - 115 - 2000 10938106
4 - 1136 - 87 - 2000 10938106
4 - 1164 - 87 - 2000 10938106
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines squamous cell carcinoma lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • homodimeric structure of CDK2AP1 including an intrinsically disordered 60-AA N-terminal region, and a phosphorylation site for IKBKE at Ser-46, which is located in the intrinsically disordered N-terminal region of the protein structure
  • a four-helix bundle dimeric structure with reduced Cys-105 in the C-terminal region
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to hamster Doc-1
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • growth suppressor
  • regulation of DNA replication
  • plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis
  • CDK2AP1 exerts its effect on stem cell
  • maintenance/differentiation through epigenetic regulation
  • plays likely an important role in modulating the growth and tumorigenesis of lung cancer cells and also has significant effects on the chemosensitivity of pulmonary malignancies
  • tumor suppressor that plays a role in cell cycle regulation by sequestering monomeric CDK2, and targeting it for proteolysis
  • knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being TP53 dependent
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alternatively, a significant fraction of reduced homo- or heterodimeric CDK2AP1 may be present prior to its activation by disulfide bond formation within the dimeric structure
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • (p180,catalytic subunit) inhibiting DNA polymerase alpha/primase by its effect on the associated CDK2 activity
  • negative regulator of CDK2 activity
  • progesterone is primary regulator of CDK2AP1 gene expression and tissue-specific expression in the uterus
  • two putative binding partners: CDK2AP2 and CDK2
  • CDK2AP1 is a substrate for IKBKE
  • suppresses cell growth, differentiation and angiogenesis in numerous types of carcinoma by interacting with certain cell cycle proteins, including CDK2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    involved in the development of breast cancer and maybe a potential therapeutic candidate to suppress tumorigenicity in breast cancer
    cancerlung 
    may serve as a new molecular target for future lung cancer therapy
    ANIMAL & CELL MODELS