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FLASH GENE
Symbol CCL1 contributors: mct - updated : 28-10-2011
HGNC name chemokine (C-C motif) ligand 1
HGNC id 10609
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 542 - 96 - 1999 10409433
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Tca-3
Homologene
FAMILY
  • intercrine beta (chemokine CC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • monocyte chemotactic protein
  • mast cell-derived CCL1- and CCR8-expressing CD4(+) effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation
  • directly drives chemotaxis in an eosinophilic cell through endogenously expressed CCR8
  • cell & other
    REGULATION
    activated by by statin administration
    induced by PMA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in bronchial epithelium from asthmatic patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses
    ANIMAL & CELL MODELS