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FLASH GENE
Symbol PRCP contributors: mct/npt - updated : 29/10/2008
HGNC name prolylcarboxypeptidase (angiotensinase C)
HGNC id 9344
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2161 51 496 - Wang, Mallela (2008)
10 - 2224 - 517 - Wang, Mallela (2008)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveesophagus   highly
 pharynx   highly
Reproductivefemale systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 179 AAs of N-terminal region could play an important role in the folding and the dimerization of the polypeptides
  • serine or threonine residues repeated as the 26th residue 7 out of 9 times
  • with identical or similar amino-acids in the other positions in the repeats
  • C-terminal region of the PRCP contributes to PRCP catalytic function
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S28 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • plasma and endothelial prekallikrein (PK) activator, cleaving C-terminal amino acids linked to proline in peptides such as angiotension II, III
  • polypeptide that folds back on itself to form a three-dimensional functional structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS