basic FUNCTION
| modulating transcriptional activation by the estrogen receptor, essential for female fertility (in mice) and potential coactivator of hormone-regulated gene |
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transcription |
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acting as a potent corepressor of transcription from the SF-1 responsive cAMP regulatory sequence 2 (CRS2) element of the CYP17 gene and a variety of SF-1 responsive promoter genes |
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atypical transcription inhibitor playing, by repressing nuclear hormone receptor activity, a fundamental role |
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via its interplay with other coregulators, plays a fundamental role in determining both the normal and pathogenic physiological state |
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having a a role as an activator of specific networks of genes in the liver |
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playing a fundamental role in mitochondrial activity |
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modulating transcriptional activity of the estrogen receptor |
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functional role in chromatin remodeling to repress hormone target gene expression (Park 2009) |
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transcriptional coregulator NRIP1 regulates intestinal homeostasis and tumorigenesis |
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inhibited intestinal epithelial cell proliferation and apoptosis |
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tumor suppressor role for NRIP1 in colon cancer |