basic FUNCTION
| expressed and presented by human glioma cells |
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playing a putative role in tumorigenic reversion and may be controling cell proliferation |
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could induce tumor cell apoptosis |
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suppresses the proliferation and tumorigenicity of human breast cancer cells, and inhibits mammary tumor growth in an orthotopic tumor model |
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suppresses nuclear factor-kappaB transcriptional activity and desensitizes tumor necrosis factor-alpha-mediated nuclear factor-kappaB activation |
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an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1 |
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a major activator of caspase-1 in response to cytoplasmic DNA |
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a receptor for cytosolic dsDNA, which forms a new inflammasome complex with ASC to activate caspase-1-mediated processing of IL1b |
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activation of the AIM2 inflammasome is important in innate immunity to vaccinia virus |