protein
| interaction with RPL5, ATP-dependent and likely contributing to the nucleolar translocation of NVL |
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binding partner of NVL |
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is a novel TERT-interacting protein (NVL interacts and co-localizes with TERT in the nucleolus) |
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NVL is a remodeling factor for the MTREX-exosome complex during the maturation of pre-ribosomal particles |
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WDR74 is a factor that specifically dissociates from the complex depending on the ATPase activity of NVL |
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WDR74 is a novel regulatory protein of the MTREX-exsosome complex whose interaction is regulated by NVL and is involved in ribosome biogenesis |
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WDR74 associates with the D1 AAA domain of NVL, which represents a novel mode of binding of a substrate with a type II AAA-ATPase |
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WDR74 associates with MTREX, the nuclear exosome-assisting RNA helicase, whose dissociation is prohibited by an ATPase-deficient mutant of the AAA-type chaperone NVL |
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WDR74 is a MTREX-interacting partner, whose dissociation is stimulated by the ATP hydrolysis of NVL |