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FLASH GENE
Symbol SIPA1L1 contributors: mct - updated : 08/10/2008
HGNC name signal-induced proliferation-associated 1 like 1
HGNC id 20284
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 6028 - 1804 - Olsen (2006)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunelymph node   highly
 spleen   highly
Nervousbrain    
 spinal cord    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PDZ/DHR domain
  • one RAP-GAP domain
  • HOMOLOGY
    interspecies homolog to murine Spa-1 2
    homolog to C.elegans T27F2.2
    homolog to rat Spar
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • GTPase-activating protein specific for Rap1 and Rap2, postsynaptic actin regulatory protein
  • involved in actin remodeling, RAP signaling, and spine morphogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SNK
  • binding to HPV 16 E6
  • cell & other
    REGULATION
    Other degraded by SNK
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS