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FLASH GENE
Symbol ENPEP contributors: mct/np - updated : 01-04-2008
HGNC name glutamyl aminopeptidase (aminopeptidase A)
HGNC id 3355
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 5004 109.3 957 - Engenheiro (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Nervousbraindiencephalonhypothalamus predominantly Homo sapiens
 brainforebraincerebral cortex highly Homo sapiens
 brainhindbrainmedulla oblongata highly Homo sapiens
 plexus choroid   predominantly Homo sapiens
Urinarykidneynephronrenal capsuleglomerulushighly
 kidneytubuleconvoluted tubuleproximal tubulehighly
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • large extracellular domain
  • a zinc binding motif typical of zinc dependent metallohydrolase
  • HOMOLOGY
    interspecies homolog to murine B-lymphocyte differentiation antigen BP-1/6C3
    Homologene
    FAMILY
  • peptidase M1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text integral type 2 membrane protein
    basic FUNCTION
  • cleaves aspartic and glutamic acidic residues from the N-terminus of a number of protein substrates that includes angiotensin II
  • implicating in the degradation of angiotensinogen II to angiotensinogen III in the brain and the kidney
  • integral component of the brain renin angiotensin system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to focal and segmental glomerulosclerosis (FSGS)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be clinically tested as an additional therapy for the treatment of certain forms of hypertension
    ANIMAL & CELL MODELS