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FLASH GENE
Symbol TSN contributors: mct - updated : 30-12-2015
HGNC name translin
HGNC id 12379
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3408 - 228 - 2005 15987823
5 - 3328 - 148 - 2005 15987823
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouthtongue  highly
Nervousbrain   highly
Reproductivemale systemtestis   
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DNA binding domain formed in the ring-shaped structure in combination with its basic region
  • a functional nuclear export signal
  • secondary structure
  • asymmetric octamer barrel consisting of six translin and two TSNAX subunits
  • mono polymer homomer , heteromer , hexamer
    HOMOLOGY
    interspecies ortholog to murine Tb-Rbp
    Homologene
    FAMILY
    CATEGORY DNA associated , RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • control of recombination at d(GT)n, d(AC)n microsatellites and maintenance of telomeres
  • dimerizing DNA binding protein at the breakpoint junctions in chromosomal translocations
  • may be involved in the control of recombination at d(GT)n.d(AC)n microsatellites and in telomere maintenance
  • is a key activator of the core RNAi machinery
  • TSN and TSNAX play a central and important role in eukaryotic cell biology
  • functions as an octamer, but in the octameric crystallographic structure, the residues responsible for nucleic acid binding are not accessible
  • single-stranded DNA (ssDNA)/RNA binding protein, likely involved in chromosomal translocations, telomere metabolism, and mRNA transport and translation
  • CELLULAR PROCESS nucleotide, recombination
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with TSNAX and associated TSNAXIP1
    INTERACTION
    DNA single stranded microsatellitesrepeats d(GT)n, telomeric repeats
    RNA binding
    small molecule
    protein
  • interaction with TSNAX (the subcellular locations of TSN and TSNAX in male germ cells are modulated by the relative ratios of TSNAX and TSN)
  • RNF139 is a target of Translin (TSN), a posttranscriptional regulator of genes transcribed by the transcription factor CREM-tau in postmeiotic male germ cells
  • TSN and TSNAX play a central and important role in eukaryotic cell biology
  • can bind single-stranded sequences internally embedded in dsDNA molecules
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS