protein
| exportin (XPO1) |
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the E2 enzyme UBE2I (UBC9) |
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modifying HDAC4 and HDAC-1 and -6 deacetylases |
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modifying MITR |
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interacts with interphase microtubules through its N-terminal region and modulates their stability |
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through kinesin-binding domain (KBD) associated selectively in the central nervous system (CNS), and directly, with the ubiquitous and CNS-specific kinesins, KIF5B and KIF5C, respectively, but not with the highly homologous KIF5A |
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APC interacts with RANBP2, a microtubule-binding nucleoporin |
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with RAN, anchor RAPGEF3 to the nuclear pore, permitting cAMP signals to activate RAP1A at the nuclear envelope) |
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KPNB1 having functions at kinetochores exerted via RANBP2 and opposed by XPO1 |
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cellular RANBP2 is quantitatively associated with RANGAP1, indicating that complexed rather than free RANBP2 is the relevant E3 ligase |
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nuclear transport receptors KPNB1 and XPO1 play essential roles in localising the RANBP2-SUMO-RANGAP1 complex away from, or at kinetochores, respectively |