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FLASH GENE

Symbol

SLC25A6

contributors: mct - updated : 31-03-2020

HGNC name	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
HGNC id	10992

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	liver isoform

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001636 4 - 1451 NP_001627 - 298 - 1993 8486369

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           salivary gland       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

physiological period

embryo

Text

tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three tandemly repeated mitochondrial carrier protein domains
	three Solcar repeats

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to chicken slc25a5

Homologene

FAMILY

mitochondrial carrier family

CATEGORY

enzyme , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner

basic FUNCTION	adenine nucleotide translocator 3, ADP/ATP translocase
	has a potential role in Th cell survival and immune cell homeostasis
	is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis
	plays a contributive role in camptothecin (CPT)-induced apoptosis through induction of mitochondrial permeability transition pore (MPTP)
	export the ATP produced by oxidative phosphorylation (OxPhos) from the mitochondria into the cytosol while importing ADP

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

mitochondrial transport

PATHWAY

metabolism

energetic

signaling

a component	component of oxidative phosphorylation (OXPHOS)
	complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5) at the inner mitochondrial permeability transition pore

INTERACTION

DNA

RNA

small molecule

protein	SLC25A6 is a previously unknown HSPA9 substrate and cell survival/death effector
	HSPA9 facilitates BRAF-mutant tumor cell survival by suppressing SLC25A6-mediated mitochondrial membrane permeability

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         decreased cellular ATP levels, limited cell growth and induced a stress-like response

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS