SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
text
| prenylated and prenylation is required for the membrane association |
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GBP1, GBP3, and GBP5 were exclusively detected in the cytoplasm, whereas GBP2 and GBP4 displayed a nucleocytoplasmic distribution |
basic FUNCTION
| GTPase converting GTP to GMP |
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mediating an antiviral effect against stomatites virus and encephalomyocarditis virus |
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key mediator of the inhibitory effects of inflammatory cytokines on endothelial cells proliferation and invasiveness |
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acting as a major regulator of the anti-angiogenic response of endothelial cells to inflammatory cytokines |
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may be used as a marker to monitor the inflammatory cytokines (IC)-induced phenotype of endothelial cells (EC) in inflammation and may also be exploited as a target to modulate EC activity in inflammatory diseases and tumor angiogenesis |
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marker and intracellular regulator of the inhibition of proliferation, migration and invasion of endothelial cells induced by several pro-inflammatory cytokines |
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contributes to vascular dysfunction in chronic inflammatory diseases by inhibiting endothelial progenitor cells (EPC) angiogenic activity via the induction of premature EPC differentiation |
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GBP1, GBP2 and GBP5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner |
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GBP1 and GBP3 possess anti-influenza viral activity |
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acts directly as a tumor suppressor in colorectalcarcinoma and the loss of GBP1 expression might indicate tumor evasion from the IFNG-dominated Th1 immune response |
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plays an important role in antitumor and antiviral immune responses |
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is a novel member within the family of actin-remodeling proteins specifically mediating IFNG-dependent defense strategies |
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IFNG-inducible guanylate binding protein 1 (GBP1) is a regulator of T cell activation |