basic FUNCTION
| signal transducer and activator of transcription of the GH/PRL JAK/STAT pathway |
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molecular regulator of proliferation, differentiation, and apoptosis in lymphohematopoietic cells (Mahajan 2001) |
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playing a critical role for many, but not all, aspects of steady state lymphoid lineage development and maintenance |
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required for thymopoiesis in a development stage-specific manner |
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can induce a TP53- and Rb-dependent cellular senescence response (Mallette 2007) |
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critical transcription factor for a number of physiological processes including hematopoiesis and mammary gland development (Iyer 2008) |
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signal transducer and activator of transcription 5A and 5B (STAT5A/B) is critical for the viability of prostate cancer cells (Tan 2008) |
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STAT5A/B directs GM-CSF signaling through the regulation of proliferation and survival genes (Kimura 2009) |
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plays a pivotal role in the proliferation, secretory differentiation, and survival of mammary epithelial cells |
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critically regulates human dendritic cells (DC) development, with specific requirements for the level of STAT5A activation at distinct differentiation stages |
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negatively regulates T follicular helper (Tfh) cell generation and function (pMID: 22318729) |
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critical role of STAT5A, STAT5B transcription factor tetramerization for cytokine responses and normal immune function |
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its activation may modulate the differentiation of T helper cells through attenuation of TGFB1 stability and production |
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STAT5A regulates the secretion of autocrine proangiogenic factors |
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unphosphorylated STAT5A functions as a tumor suppressor capable of repressing multiple oncogenes via heterochromatin formation |
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STAT5B and STAT5A act partly as non-redundant transcription factors and that STAT5B is more critical for Treg maintenance and function in humans |
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is an early step in establishing transcription complexes on genes specifically expressed in mammary epithelium |
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plays an important role in ABCG2 expression during lactation |
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STAT5A activates distal-less homeobox 5 (DLX5) in human bone marrow-derived stromal cells (hBMSCs) and enhances osteogenesis |
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STAT5A inhibition enhances bone formation by promoting osteogenesis of BMSCs |