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FLASH GENE
Symbol TMED10 contributors: mct - updated : 23-02-2012
HGNC name transmembrane emp24-like trafficking protein 10 (yeast)
HGNC id 16998
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4163 23 219 - 2009 19710022
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Nervousnerve    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in the brain is high during embryonic development and then declines after birth
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a serine protease domain
  • a scavenger cysteine-rich domain
  • a LDL receptor class A domain
  • a GOLD domain
  • a transmembrane domain promoting its association with the presenilin complex that results in decreased gamma-cleavage activity
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Emp24p
    homolog to murine Tmed10 (92.2pc)
    homolog to rattus TMP21 (92.7pc)
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    text type I membrane protein; golgi cisternae
    basic FUNCTION
  • involved in vescular protein trafficking
  • differentially regulating gamma-secretase cleavage without affecting epsilon-secretase activity
  • transmembrane protein involved in endoplasmic reticulum/Golgi transpor
  • member of the p24 cargo-protein family that is involved in vesicular targeting and protein transport
  • presenilin complex component that modulates gamma- but not epsilon-secretase activities
  • behaves as a regulator of gamma- but not epsilon-cleavages generated by presenilin-dependent gamma-secretase complex
  • TMED2, TMED10 are specific cargo receptors of GPCRs and differentially control GPCR trafficking in the biosynthetic pathway, and thereby, TMED2 and TMED10 regulate GPCR signaling in astrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of presenilin complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with gamma-secretase, and negatively regulates beta-amyloid production
  • interact with presenilin complexes
  • cell & other
    REGULATION
    Other degradation of TMED10, as with the other presenilin-associated gamma-secretase complex members, is mediated by the ubiquitin-proteasome pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the brains of individuals with AD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    ability of the TMED10 peptide to alter APP processing and Abeta production could represent a novel strategy for modulating amyloid production and its subsequent pathology
    ANIMAL & CELL MODELS