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FLASH GENE
Symbol ACSL3 contributors: mct - updated : 11-10-2017
HGNC name acyl-CoA synthetase long-chain family member 3
HGNC id 3570
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas     Homo sapiens
Nervousbrain   highly
Reproductivemale systemtestis   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
25-amino-acid consensus sequence,(FACs signature motif)
HOMOLOGY
interspecies homolog to murine Facl3
Homologene
FAMILY
  • long-chain-fatty-acid-coenzyme A ligase family
  • ATP-dependent AMP-binding enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • converting free long-chain fatty acid into fatty acyl-CoA esters
  • playing a role in lipid biosynthesis and fatty acid degradation
  • using preferentially myristate,laurate,arachidonate and eicosapentaenoate as substrates
  • involvement of ACSL4 and ACSL3 in insulin secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
  • protein
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS