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FLASH GENE
Symbol IL13RA2 contributors: mct - updated : 25-08-2007
HGNC name interleukin 13 receptor, alpha 2
HGNC id 5975
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Reproductivefemale systemuterus   
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text only in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal FBN- type III like domain
  • a short C terminal intracellular tail
  • the WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor bindi
  • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be involved in susceptibility to systemic sclerosis
  • play a role in the internalization of IL13
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subuint of the interleukin 13 receptor complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS