basic FUNCTION
| central posttranscriptional regulator of cellular and systemic iron metabolism, undergoes proteasomal degradation in iron-replete cells |
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master regulator of cellular iron metabolism |
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binding to the transferrin receptor mRNA inhibiting the degradation of this otherwise rapidly degraded mRNA |
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RNA-binding protein that post-transcriptionally control the mRNA of proteins involved in storage, transport, and utilization of iron (Dycke 2007) |
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major role of ACO1, and IREB2 in cell biology: to ensure adequate iron supply to the mitochondrion for proper function of this critical organelle |
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controls the synthesis of many proteins involved in iron metabolism, and the level of IREB2 itself is regulated by varying the rate of its degradation |