SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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text
| translocated to nucleus after heat shock activation |
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localized to the centrosome in mitosis and especially to the spindle poles in metaphase |
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normally shuttles between the nucleus and the cytoplasm, but, when activated by stressors |
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upon heat shock, HSF1 is phosphorylated, trimerizes, and translocates to the nucleus |
basic FUNCTION
| involved in transcriptional activation of heat shock genes |
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can activate ABCB1 expression in a stress-independent manner that differs from the canonical heat shock-activated mechanism involved in HSP induction |
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reported to induce genomic instability and aneuploidy by interaction with CDC20 |
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maternal transcription factor essential for normal progression of meiosis |
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involved in several specialized cell functions (e.g. placenta formation, immunity, placode development, cancer cell viability) and is essential for female reproduction |
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plays a critical part in the regulation of oocyte meiosis and that this can be linked to its transcriptional regulation of HSP90A1, the prominent chaperone expressed in oocytes |
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playing an essential role for protecting cells from protein-damaging stress associated with misfolded proteins and regulating the insulin-signaling pathway and aging |
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required for TP53 nuclear importation and activation and implies that heat shock factors play a role in the regulation of TP53 |
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required for establishment of the microtubule network in cells and for nuclear localization of TP53 |
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transcription factor that plays a key role in the response to heat stress and was previously shown by us to also be essential for importation of p53 into the nucleus |
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plays an important role in checkpoint activation and DNA repair |
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required for oocyte maturation, the adult phase of meiosis preceding fertilization |
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master transcriptional regulator of the cellular response to heat and a wide variety of other stressors |
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master regulator of the heat-shock response |
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engages a regulatory program in the highly malignant state that is distinct from the classic heat-shock response |
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winged helix transcription factor that plays roles in control and stressed conditions by gaining access to target elements |
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modulates the expression of the cell survival heat shock protein 70 (HSP70) and the cell death T-cell death associated gene 51 (TDAG51) in response to heat shock and various other cell stressors |
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is induced in both cell types, epithelial cells and fibroblasts |
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critical role for HSF1 in controlling cytoprotective autophagy through regulation of ATG7, which is distinct from the HSF1 function in the heat shock response |