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FLASH GENE
Symbol CASP4 contributors: shn/npt/pgu - updated : 02-06-2015
HGNC name caspase 4, apoptosis-related cysteine peptidase
HGNC id 1505
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 1352 - 321 - 1999 9931493
  • transcript variant gamma
  • 9 splicing 1319 - 377 - 1999 9931493
  • transcript variant alpha
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon lowly
     intestinesmall intestine  highly
     liver   moderately
    Endocrinepancreas   lowly
    Lymphoid/Immunespleen   highly
     thymus   lowly
    Reproductivefemale systemovary  highly
     female systemplacenta  highly
     male systemprostate  lowly
     male systemtestis  lowly
    Respiratorylung   moderately
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
  • a conserved QACXG pentapeptide active site motif
  • mono polymer heteromer , dimer
    isoforms Precursor precursor producing two subunits,large and small,that dimerize
    HOMOLOGY
    interspecies homolog to mammalian interleukin 1 beta convertase (IL1BC)
    ortholog to Casp4, Mus musculus
    ortholog to Casp4, Rattus norvegicus
    ortholog to CASP4, Pan troglodytes
    Homologene
    FAMILY
  • cysteine-aspartic acid protease (caspase) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
  • ocalized to the ER membrane
  • basic FUNCTION
  • involved in Fas-mediated apoptosis
  • cysteine containing aspartate-specific protease, potentially involved in procytokine activation
  • promoting apoptosis
  • a key mediator of apoptosis and inflammation in human retinal pigment epithelial cells
  • required for non-canonical inflammasome-triggered macrophage cell death, indicating that caspase-11 (CASP4) orchestrates both caspase-1-dependent and -independent outputs
  • a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • direct interaction of APBB1 and TSHZ3 with the promoter region of CASP4
  • RNA
    small molecule
    protein
  • cleaving and activating CASP1
  • NALP1
  • Caspase-14, CASP14 (Hu et al, 1998)
  • TNF receptor-associated factor 6, TRAF6
  • IFNA1 may possess anti-cervical cancer capacity by activating cell apoptosis via the intrinsic mitochondrial pathway and CASP4-related ER stress-induced pathway
  • cell & other
    REGULATION
    inhibited by inhibitor 9, PI9
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • knock-down of CASP4 by siRNA reduces NF-kappaB activation and nuclear translocation
  • Casp11(-/-) mice, exhibited defects in IL-1&
  • 946; production and harboured a mutation in the Casp11 locus that attenuated caspase-11 expression
  • loss of caspase-11 rather than caspase-1 protected mice from a lethal dose of lipopolysaccharide