basic FUNCTION
| regulates the interactions between components of adherens-type junctions and organizes the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells |
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involved in the restructuring of the cortical actin cytoskeleton |
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a key regulator of cell migration |
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filamentous actin binding protein, modulating F-actin polymerization and cell migration through overexpression and/or tyrosine phosphorylation |
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can contribute to cell polarity by controlling the extent of ARPCs activation by WASP family members and the stability of the F-actin network |
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cortactin-mediated actin remodeling in excitable cells is not only important for cell structure, but may directly impact membrane excitability |
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contributes to KCNA2 endocytosis by complexing with dynamin |
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major target for tyrosine phosphorylation |
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its role would switch from a scaffold linking KCNA2 to the cortical actin cytoskeleton to a proximal protein capable of facilitating channel endocytosis through actin remodeling |
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playing an important role in CXCR4 signaling and trafficking as well in the receptor-mediated cell migration |
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involved in keratinocyte migration promoted by both FGF7 and FGF10) |
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critical mediator of tumor cell invasion |
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cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes |
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synergize with N-WASP for ARCTs-dependent actin polymerization |
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actin-binding protein enriched in lamellipodia of motile cells and at dynamic actin structures such as membrane ruffles |
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plays important roles in vesicular transport, receptor |
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downregulation, post-Golgi transport and endocytosis |
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involved in tumor metastasis |
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with DNM2, functions as a dynamic actin filament remodeling complex that influences the global organization of the actomyosin cytoskeleton |
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multifunctional regulator of cellular invasiveness |
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controls cell motility and lamellipodial dynamics by regulating extracellular matrix (ECM) secretion |
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phosphorylation regulates cell invasion through a pH-dependent pathway |
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DBNL and cortactin (CTTN) play distinct roles in podosome regulation |
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actin-binding protein, is essential for cell growth and motility |
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branched actin regulator and tumor-overexpressed protein that promotes vesicular trafficking at a variety of cellular sites, including endosomes and the trans-Golgi network |
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involved in regulation of late endosomal/lysosomal maturation and trafficking that affects Golgi morphology |
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role for CTTN acetylation in the regulation of DLG4 dendritic clustering, which may work in concert with cortactin role in spine development |
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is a key scaffold for actin regulation at the zonula adherens (ZA), which localizes to the ZA through influences from both CDH1 and WASL |
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phosphorylated CTTN may facilitate the recruitment of PFN1 to the cell edge, which promotes localized actin polymerization, leading edge formation, and cell movement |
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actin-interacting protein, implicated in cytoskeletal architecture and often amplified in several types of cancer |
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both CTTN and FSCN1 play key roles in extracellular vesicles (EVs) release by regulating endosomal trafficking or invadopodia formation and function |