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FLASH GENE

Symbol

AANAT

contributors: mct - updated : 17-01-2009

HGNC name	arylalkylamine N-acetyltransferase
HGNC id	19

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 1014 isoform 1 - 207 - Blomeke (2008)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye retina       Homo sapiens

cell lineage
cell lines	retinoblastoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	acetyltransferase family
	AANAT subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	penultimate step in melatonin synthesis, controlling its circadian rhythm production
	modulating the function of the circadian clock in the supra optical nucleus and influencing activity and sleep
	catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis
	controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

circadian

PATHWAY

metabolism

hormone

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

controlling the circadian rhythm of melatonin production

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to delayed sleep phase syndrome

Variant & Polymorphism SNP	significantly associated with the delayed sleep phase syndrome

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS